The Use of Genetic Markers to Determine Risk for Prostate Cancer at Prostate Biopsy

摘要: Purpose: We examined a panel of 13 polymorphisms in different genes to determine whether specific genotypes can help predict prostate cancer at the time biopsy among men prescreened with prostate-specific antigen and digital rectal exam. Experimental Design: 2,088 consecutive who were referred for from 1997 2003. Thirteen examined, including TNF308, GSTT1, KLK2, endostatin, MCRA, MCRV, tyrosinase, MSR1, CHK2, RNasel, HOGG1-326, HOGG1-11657, HRAS1 . Odds ratio detection adjusted age, race, antigen, exam, family history cancer, urinary symptoms. Results: Of men, 996 (47.7%) had detected. Four ( KLK2 , HOGG1-326 ) significantly associated cancer. The odds ratios (OR) patients AA genotype TNF308 gene was 1.92 [95% confidence interval (95% CI), 1.0-1.5, P = 0.05], compared those GG genotype, TT gene, OR 1.5 interval, 1.0-2.2, 0.04), CC genotype. homozygous deletion GSTT1 0.81 CI, 0.6-1.0, 0.06) deletion, 0.68 0.5-1.0, 0.05) Patients all four alleles that positively an 9.33 2.4-35.8, 0.0005) negatively Conclusions: polymorphisms, two found be ). Future studies are required confirm these results.