Evaluating Hormone Therapy-associated Increases in Breast Density

摘要: Rationale and Objectives Changes in breast density, which are commonly associated with hormone replacement therapy (HRT) use, may imply changes cancer risk. This study explores the ability of different methods to detect (HRT)-associated increases density. Materials Methods Between 1997 2001, 51 postmenopausal women were reported have HRT-associated density at our institution. Twenty not an increase during same period selected as controls. Mammograms from date report earlier comparison used. Breast Imaging Reporting Data System (BI-RADS) categories both dates obtained mammography report. reviewed separate time points evaluated by assigning BI-RADS categories, visual assessment, computer-assisted quantitative analysis. Results Mammogram reports available for two patients. The remaining 49 HRT included. Reported resulted detection 57%, simultaneous assignment 61%, assessment 100%, 94% category change was only method that false-positive control Minimal most difficult detect, 90% these 21 cases detected 3 when defined least 5%. Conclusion Visual best identified including those minimal increases. Simultaneous considerably better than use categories. information be helpful guiding research design studies evaluating use.