Renal function in children with heart transplantation after switching to CNI‐free immunosuppression with everolimus

摘要: Renal impairment because of CNI contributes to long-term morbidity. Therefore, avoiding or sparing treatment strategies are important. In this article, we describe the results a CNI-free protocol with regard recovery renal function. Twenty-eight patients heart transplantation were switched from regimen everolimus and mycophenolate, when cGFR was <75 mL/min/1.73 m(2). all patients, stopped, trough levels 5-8 ng/L achieved. Serum creatinine determined before after 6 12 months. Median serum decreased 1.2 mg/dL (range 0.7-3.7) 1.0 0.6-1.8) 0.5-1.9) 47.81 18.3-72.6) m(2) 63.1 37.8-108.7) at six months 64.8 37.7-106.6) All changes baseline statistically significant (p < 0.05). Adverse events infections (n = 3) rejections 3). Therapy discontinued in four patients. Conversion immunosuppression resulted improvements function within withdrawal. Side effects common. However, more studies required demonstrate effectiveness children.