Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis.
作者： Chih-Chieh Hsu , Ron-Bin Hsu , Ryosuke Ohniwa , Jeng-Wei Chen , Chang-Tsu Yuan
关键词:
摘要: The mechanisms or host factors involved in septic thrombus vegetation formation Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental rat model, here we demonstrated that S. aureus HG001-induced was composed of bacterial floes encased aggregated platelets and surrounded by neutrophil extracellular traps (NETs). In vitro data contribute to both biofilm NET formation. Prophylactic administration DNase I significantly reduced the size induced methicillin-resistant (MRSA) methicillin-sensitive (MSSA) strains, even though MRSA MSSA isolates express different phenotypes NET-induction abilities presence platelets. Moreover, delivery daptomycin prophylactically therapeutically produced synergistic effects reducing numbers on damaged valve tissues MRSA-induced IE. Together, these suggest NETs has potential control IE clinic.
elsevier.com
ntu.edu.tw
thieme-connect.de参考文章(36)
Steven Y. C. Tong, Joshua S. Davis, Emily Eichenberger, Thomas L. Holland, Vance G. Fowler, Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management Clinical Microbiology Reviews. ,vol. 28, pp. 603- 661 ,(2015) , 10.1128/CMR.00134-14
Larry M Baddour, Walter R Wilson, Arnold S Bayer, Vance G Fowler Jr, Imad M Tleyjeh, Michael J Rybak, Bruno Barsic, Peter B Lockhart, Michael H Gewitz, Matthew E Levison, Ann F Bolger, James M Steckelberg, Robert S Baltimore, Anne M Fink, Patrick O’Gara, Kathryn A Taubert, American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council, None, Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications A Scientific Statement for Healthcare Professionals From the American Heart Association Circulation. ,vol. 132, pp. 1435- 1486 ,(2015) , 10.1161/CIR.0000000000000296
Kelly C Rice, Ethan E Mann, Jennifer L Endres, Elizabeth C Weiss, James E Cassat, Mark S Smeltzer, Kenneth W Bayles, The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 8113- 8118 ,(2007) , 10.1073/PNAS.0610226104
Jean-San Chia, Ya-Lin Lin, Huei-Ting Lien, Jen-Yang Chen, Platelet Aggregation Induced by Serotype Polysaccharides from Streptococcus mutans Infection and Immunity. ,vol. 72, pp. 2605- 2617 ,(2004) , 10.1128/IAI.72.5.2605-2617.2004
Leon Iri Kupferwasser, Michael R. Yeaman, Shelley M. Shapiro, Cynthia C. Nast, Paul M. Sullam, Scott G. Filler, Arnold S. Bayer, Acetylsalicylic Acid Reduces Vegetation Bacterial Density, Hematogenous Bacterial Dissemination, and Frequency of Embolic Events in Experimental Staphylococcus aureus Endocarditis Through Antiplatelet and Antibacterial Effects Circulation. ,vol. 99, pp. 2791- 2797 ,(1999) , 10.1161/01.CIR.99.21.2791
Mia Phillipson, Paul Kubes, The neutrophil in vascular inflammation. Nature Medicine. ,vol. 17, pp. 1381- 1390 ,(2011) , 10.1038/NM.2514
Kazuya Morikawa, Aya J. Takemura, Yumiko Inose, Melody Tsai, Le Thuy Nguyen Thi, Toshiko Ohta, Tarek Msadek, Expression of a Cryptic Secondary Sigma Factor Gene Unveils Natural Competence for DNA Transformation in Staphylococcus Aureus PLOS Pathogens. ,vol. 8, ,(2012) , 10.1371/JOURNAL.PPAT.1003003
Stephen E Malawista, Anne de Boisfleury Chevance, Craig N Jenne, Bryan G Yipp, Paul Kubes, Keir Pittman, Kunyan Zhang, Kaiyu Wu, Björn Petri, H Christopher Meijndert, Brittney N V Scott, Lori D Zbytnuik, Davide Salina, Muhammad Asaduzzaman, John Conly, Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo Nature Medicine. ,vol. 18, pp. 1386- 1393 ,(2012) , 10.1038/NM.2847
J. F. Mustard, D. W. Perry, N. G. Ardlie, M. A. Packham, Preparation of Suspensions of Washed Platelets from Humans British Journal of Haematology. ,vol. 22, pp. 193- 204 ,(1972) , 10.1111/J.1365-2141.1972.TB08800.X
Damon P. Eisen, Arnold S. Bayer, Aspirin Use in Infective Endocarditis Clinical Infectious Diseases. ,vol. 46, pp. 1481- 1482 ,(2008) , 10.1086/587181