African KhoeSan ancestry linked to high-risk prostate cancer
作者： Desiree C Petersen , Weerachai Jaratlerdsiri , Abraham Van Wyk , Eva KF Chan , Pedro Fernandez
DOI: 10.1186/S12920-019-0537-0
关键词:
摘要: Genetic diversity is greatest within Africa, in particular the KhoeSan click-speaking peoples of southern Africa. South African populations represent admixture fractions including differing degrees African, African-KhoeSan and non-African genetic ancestries. Within United States, ancestry has been linked to prostate cancer presentation mortality. Together with environmental contributions, genetics a significant risk factor for high-risk cancer, defined by pathological Gleason score ≥ 8. Using genotype array data merged informative reference data, we investigate contribution ancestral cancer. Our study includes 152 men (Black) or African-admixed (Coloured) ancestries, which 40% showed were determined averaging an equal Coloured; found be (P-value = 0.0477). Adjusting age, associated fraction was driven over Bantu contribution, score ≥ 8 (P-value = 0.02329) specific antigen levels ≥20 ng/ml (P-value = 0.03713). Additionally, observed mean overall increased Black patients (11.8%) low-risk (10.9%) disease. Linking first time common modern disease, namely tested this small validity using as surrogate identifying potential loci. As such, identified four loci chromosomal regions 2p11.2, 3p14, 8q23 22q13.2 (P-value = all age-adjusted < 0.01), two have previously suggests that ancient may diseases, specifically those late onset therefore unlikely undergone exclusive selective pressure. such show uniquely admixed population link between explain 2-fold increase Africans compared Americans.
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