Pioglitazone inhibits EGFR/MDM2 signaling-mediated PPARγ degradation

作者: Juanjuan Shi , Wenbo Zhang , Mengli You , Ying Xu , Yongzhong Hou

DOI: 10.1016/J.EJPHAR.2016.09.010

关键词:

摘要: … and degradation, but PPARγ agonist pioglitazone reversed this event. More importantly, pioglitazone … Therefore, our study revealed a novel mechanism that pioglitazone inhibited EGFR/…

参考文章(32)
Richard S. Hotchkiss, Andreas Strasser, Jonathan E. McDunn, Paul E. Swanson, MECHANISMS OF DISEASE Cell Death The New England Journal of Medicine. ,vol. 361, pp. 1570- 1583 ,(2009) , 10.1056/NEJMRA0901217
E A Williamson, J W Said, T Kubota, K Koshizuka, H Asou, H P Koeffler, S Holden, I Miyoshi, Ligand for Peroxisome Proliferator-activated Receptor γ (Troglitazone) Has Potent Antitumor Effect against Human Prostate Cancer Both in Vitro and in Vivo Cancer Research. ,vol. 58, pp. 3344- 3352 ,(1998)
Ferdinand Hofstädter, Wolf-Ferdinand Wieland, Jörg Ellinger, Philip Kahl, Dirk Engehausen, Arndt Hartmann, Stefan C. Müller, Christine Stoehr, Bernhard Walter, Sebastian Rogenhofer, Enhanced Expression of Peroxisome Proliferate-activated Receptor Gamma (PPAR-γ) in Advanced Prostate Cancer Anticancer Research. ,vol. 32, pp. 3479- 3483 ,(2012)
G Y Zhang, N Ahmed, C Riley, K Oliva, G Barker, M A Quinn, G E Rice, Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma British Journal of Cancer. ,vol. 92, pp. 113- 119 ,(2005) , 10.1038/SJ.BJC.6602244
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
Shuji Ogino, Kaori Shima, Yoshifumi Baba, Katsuhiko Nosho, Natsumi Irahara, Shoko Kure, Li Chen, Saori Toyoda, Gregory J. Kirkner, Y. Lynn Wang, Edward L. Giovannucci, Charles S. Fuchs, Colorectal Cancer Expression of Peroxisome Proliferator-Activated Receptor γ (PPARG, PPARgamma) Is Associated With Good Prognosis Gastroenterology. ,vol. 136, pp. 1242- 1250 ,(2009) , 10.1053/J.GASTRO.2008.12.048
Colin N. A. Palmer, Mei-Hui Hsu, Keith J. Griffin, Eric F. Johnson, Novel Sequence Determinants in Peroxisome Proliferator Signaling Journal of Biological Chemistry. ,vol. 270, pp. 16114- 16121 ,(1995) , 10.1074/JBC.270.27.16114
Y Hou, Z Zhang, Q Xu, H Wang, Y Xu, K Chen, Inhibitor of growth 4 induces NFκB/p65 ubiquitin-dependent degradation Oncogene. ,vol. 33, pp. 1997- 2003 ,(2014) , 10.1038/ONC.2013.135
S. Saad, J. Zhang, R. Yong, D. Yaghobian, M. G. Wong, D. J. Kelly, X. M. Chen, C. A. Pollock, Role of the EGF receptor in PPARγ-mediated sodium and water transport in human proximal tubule cells Diabetologia. ,vol. 56, pp. 1174- 1182 ,(2013) , 10.1007/S00125-013-2835-Y