Herinase: a novel bi-functional fibrinolytic protease from the monkey head mushroom, Hericium erinaceum.
作者： Bong-Suk Choi , Kumar Sapkota , Jun-Hui Choi , Chang-ho Shin , Seung Kim
DOI: 10.1007/S12010-013-0206-2
关键词:
摘要: Herinase, a new bi-functional fibrinolytic metalloprotease, was purified from a medicinal and edible mushroom Hericium erinaceum. The enzyme was monomeric with a molecular mass of 51 kDa. Analysis of fibrin zymography showed an active band with a similar molecular mass. The N-terminal sequence of herinase VPSSFRTTITDAQLRG was highly distinguished from known fibrinolytic enzymes. Moreover, the enzyme activity was strongly inhibited by EDTA and EGTA, indicating that herinase is a metalloprotease. Herinase exhibited high …
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