Promotion of Tumor Invasion by Cooperation of Granulocytes and Macrophages Activated by Anti-tumor Antibodies

摘要: We investigated the potential role of anti-tumor antibodies and tumor antigens in formation immune complexes which promote matrix degradation angiogenesis. B-cell deficient or depleted mice showed a reduction invasion metastasis. In vitro assays vivo models metastasis that anti-sTn sTn form induce granulocytes macrophages together to mediate by processes including extracellular These results suggest existence promoting response induced shed associated solid, nonlymphoid tumors.