An improved synthesis of 3,5-disubstituted isoxazoles and pyrazoles from C(α),O-dilithiooximes and C(α),N-dilithiophenylhydrazones

作者: Tammy D. Fulmer , Lisette P. Dasher , Bonni L. Bobb , Jana D. Wilson , Kimberly L. Sides

DOI: 10.1002/JHET.5570170437

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摘要: C(α),O-Dilithiooximes and C(α),N-dilithiophenylhydrazones were prepared using an excess of lithium diisopropylamide (1:3). Condensation with esters followed by acid cyclization gave isoxazoles pyrazoles.

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