Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission.

摘要: Publisher Summary This chapter focuses on GPCR (dopaminergic, cholinergic, and metabotropic glutamatergic) receptor tyrosine kinase (PDGF insulin) regulation of NMDA channel activity NMDA-mediated neurotransmission. The N-methyl- D -aspartate (NMDAR) is a ligand-gated ion that belongs to complex proteins (enzymes, receptors, scaffolding proteins) has recently been termed the NMDAR (NRC). NRC situated at postsynaptic sites in CNS strategically located regulate excitatory mechanisms by which NMDARs are modulated signaling molecules signal transduction cascades particular importance understanding synaptic transmission plasticity. In addition, several neurological disorders, for example, schizophrenia, epilepsy, Parkinson disease, ischemia/stroke, associated with an imbalance activity. Recent evidence demonstrates modulation currents dynamic process requires interaction kinases, phosphatases, intracellular calcium. interplay these molecular largely receptor- cell-type specific likely account changes onset It becoming clear work concert other proteins, Biochemical studies have revealed multiprotein places kinases phosphatases strategic locations such they able module