Effects of β-adrenergic receptor agonists on drinking and arterial blood pressure in young and old rats

摘要: These experiments examined water-drinking and arterial blood pressure responses to β-adrenergic receptor activation in young (4 mo), “middle-aged” adult (12 old (29 mo) male rats of the Brown-Norway strain. We used isoproterenol simultaneously activate β1- β2-adrenergic receptors, salbutamol selectively combination antagonist ICI 118,551 stimulate only β1-adrenergic receptors. Animals received one drug treatments, water drinking was measured for 90 min. About 1 wk later, animals same treatment measurement In some rats, levels renin aldosterone secretion response or were additional tests. Old middle-aged drank significantly less after than did also had greater reductions pressure. although equivalent across ages. The abolished prevented most observed hypotension. Renin wholly absent rats. Aldosterone reduced compared with isoproterenol, but not salbutamol. conclusion, there are age-related differences receptor-mediated that can be explained part by stimulation.