Sirtuin Deacetylases: Linking Mycobacterial Infection and Host Metabolism
作者： Lorissa Smulan , Hardy Kornfeld , Amit Singhal
DOI: 10.1007/978-3-030-56905-1_2
关键词:
摘要: Mycobacterium tuberculosis (Mtb), the causative agent of (TB), primarily targets macrophages and actively modulates host response through intricate mechanisms ranging from immune evasion to perturbation cellular metabolism. These immuno-metabolic processes are intrinsically linked via key energy sensors, including sirtuins, a family conserved NAD+-dependent deacetylases. Recent evidence suggests that Mtb has evolved manipulate cell metabolism by modulating activity sirtuins. Here, we briefly discuss mammalian sirtuins with focus on role during inflammation fibrosis, which cornerstones TB pathogenesis. Finally, highlight importance as host-directed therapies.
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