Prognostic value of subcutaneous adipose tissue volume in hepatocellular carcinoma treated with transcatheter intra-arterial therapy

摘要: Background Prognosis of patients with hepatocellular carcinoma (HCC) who undergo transcatheter intra-arterial therapies, including arterial chemoembolization and infusion chemotherapy, is affected by many clinical factors liver function tumor progression. However, the effect body composition such as skeletal muscle visceral subcutaneous adipose tissues (VAT SAT, respectively) on prognosis these remains unclear. We investigated prognostic value in HCC treated therapies. Patients methods This study retrospectively evaluated 100 therapies between 2005 2015. Areas muscle, VAT, SAT were measured computed tomography images at third lumbar vertebra level normalized height squared to calculate index, VAT index (SATI). The tissue area ratio was also calculated. Overall survival (OS) compared high- low-index groups for each composition. Furthermore, significance assessed univariate multivariate analyses using Cox proportional hazards models. Results Among indexes, only SATI could significantly differentiate OS (p=0.012). Multivariate analysis showed that (low- vs. high-SATI: HR, 2.065; 95% CI, 1.187-3.593; p=0.010), serum albumin (<3.5 ≥3.5 g/dL; 2.007; 1.037-3.886; p=0.039), alpha-fetoprotein (<20 ≥20 ng/mL; 0.311; 0.179-0.540; p<0.001), Modified Response Evaluation Criteria Solid Tumors assessment (complete response+partial response+stable disease progressive disease; 0.392; 0.221-0.696; p=0.001) indicated independent OS. Conclusion High volume associated better outcomes Elucidation mechanisms regulating may offer a new therapeutic strategy patients.