Significantly enhanced reactivities of the nucleophilic substitution reactions in ionic liquid.
作者： Dong Wook Kim , Choong Eui Song , Dae Yoon Chi , None
DOI: 10.1021/JO034109B
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摘要: We have investigated the reactivities of various metal fluorides in nucleophilic fluorination 2-(3-methanesulfonyloxypropyl)naphthalene (1) as a model compound presence 1-n-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]). The higher periodic alkali demonstrate greater reactivity. using CsF among was completed 20 min, affording desired product 2-(3-fluoropropyl)naphthalene (2a, 95%) without any byproducts. However, fluorinations earth, transition, and low under same conditions occurred rarely or not at all. also carried out facile substitutions such halogenations, acetoxylation, nitrilation, alkoxylations mesyloxyalkane 1 2-(3-bromopropyl)naphthalene (6) primary aliphatic position potassium halides, acetate, cyanide, alkoxides, respectively, ionic liquids. These reactions prov...
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