Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's disease?

作者: M. K. Magnusson , Mary Jo Wick

DOI: 10.1556/EUJMI.1.2011.1.5

关键词:

摘要: Dendritic cells and macrophages play an essential role in immune homeostasis the intestine. They have critical task of maintaining balance between tolerance to intestinal microflora potential food antigens while retaining ability initiate immunity against pathogens. For patients with Crohn’s Disease, tolerance/immunity is disturbed these individuals suffer from chronic inflammation driven by aberrant T cell reactivity bacteria. As antigen presenting are required for activation, phagocytes capacity present bacteria likely involved initiating propagating Disease. Recent data describe unique subsets human that may be commensal flora drives Disease pathogenesis. This review summarizes current knowledge phagocyte intestine mesenteric lymph nodes healthy patients. Deciphering function health disease crucial advance our understanding cellular mechanisms underlying this debilitating disease, provides a way improve treatment inflammatory bowel disease.

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