Uncharted waters: nephrogenesis and renal regeneration in fish and mammals

摘要: The major functions of the vertebrate kidney are removal metabolic waste and balance salt water. These roles fulfilled by nephrons, which generally comprise a blood filter (glomerulus) attached to an epithelial tubule. number nephrons in mammalian is set at end organogenesis late fetal or neonatal period. Subsequent increases nephron size functionality then occur during postnatal growth match body mass/fluid. Because this strategy renal development, injuries birth defects that reduce lead permanent deficit increase risk disease. In contrast mammals, fish kidneys continue add throughout their lifespan. response injury, rate nephrogenesis, effectively replacing lost maintaining endowment. A better understanding remarkable nephrogenic abilities may innovative ways restore nephrogenesis adult kidney. This review examines our current mammals explores possible explanations for why fish, but not utilize perpetual grow maintain kidneys.