Arrhythmia Predisposition: Between Rare Disease Paradigms and Common Ion Channel Gene Variants

摘要: Cardiac side effects, such as QT prolongation or occurrence of Torsade de pointes (TdP), from widely used cardiac and non-cardiac drugs are still a major challenge for physicians. Recent advances in knowledge on the physiology myocardial repolarization have made it clear that alterations ion channel genes associated with diverse vitro effects may tune normal to critical edges where ventricular arrhythmia occurs. The extent which genetic factors (aside “typical” gene mutations) susceptibility TdP remains be determined is addressed this review. Future research must: 1) identify all relevant repolarization; 2) determine variability interval response action potential genetically controlled; 3) investigate role functionally single nucleotide polymorphisms/haplotype constellations contribution 4) integrate identified other known risk, according their relative importance, network algorithm arrhythmogenesis. Gaining an understanding current genomic data patients drug-induced first steps overcoming hurdles unexpected variety drugs.