Molecular Epidemiology of Multi-Drug Resistant Pseudomonas aeruginosa Isolates from Hospitalized Patients in Greece.

作者: Olga Pappa , Anastasia Maria Kefala , Kyriaki Tryfinopoulou , Marios Dimitriou , Kostas Kostoulas

DOI: 10.3390/MICROORGANISMS8111652

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摘要: Resistant Pseudomonas aeruginosa isolates are one of the major causes both hospital-acquired infections (HAIs) and community-acquired (CAIs). However, management P. is difficult as bacterium inherently resistant to many antibiotics. In this study, a collection 75 clinical from two tertiary hospitals Athens Alexnadroupolis in Greece was studied assess antimicrobial sensitivity molecular epidemiology. All were tested for susceptibility 11 commonly used antibiotics, newly introduced Double Locus Sequence Typing (DLST) scheme implemented elucidate predominant clones. The presented various phenotypes, with Verona Integron-Mediated Metallo-β-lactamase (VIM-2) mechanisms being majority, new phenotype, FEPR-CAZS, reported first time Greek isolates. DLST revealed types, 32-39 8-37, provided evidence intra-hospital transmission clone hospitals. results indicate that can be valuable tool when local outbreaks demand immediate tracking investigation limited financial resources.

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