Modeling Subtilin Production in Bacillus subtilis Using Stochastic Hybrid Systems
作者： Jianghai Hu , Wei-Chung Wu , Shankar Sastry
DOI: 10.1007/978-3-540-24743-2_28
关键词:
摘要: The genetic network regulating the biosynthesis of subtilin in Bacillus subtilis is modeled as a stochastic hybrid system. continuous state system concentrations and various proteins, whose productions are controlled by switches that turn Markov chains. Some preliminary results given both analysis simulations.
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Jianghai Hu, John Lygeros, Shankar Sastry, Towars a Theory of Stochastic Hybrid Systems acm international conference hybrid systems computation and control. pp. 160- 173 ,(2000) , 10.1007/3-540-46430-1_16
Hybrid Systems: Computation and Control. Defense Technical Information Center. ,(1998) , 10.1007/3-540-64358-3
Madeline A. Shea, Gary K. Ackers, The OR control system of bacteriophage lambda. A physical-chemical model for gene regulation. Journal of Molecular Biology. ,vol. 181, pp. 211- 230 ,(1985) , 10.1016/0022-2836(85)90086-5
Anthony Trewavas, Much food, many problems Nature. ,vol. 402, pp. 231- 232 ,(1999) , 10.1038/46157
Ronojoy Ghosh, Claire J. Tomlin, Lateral Inhibition through Delta-Notch Signaling: A Piecewise Affine Hybrid Model acm international conference hybrid systems computation and control. pp. 232- 246 ,(2001) , 10.1007/3-540-45351-2_21
Manuela L. Bujorianu, John Lygeros, Reachability questions in piecewise deterministic Markov processes international conference on hybrid systems computation and control. pp. 126- 140 ,(2003) , 10.1007/3-540-36580-X_12
P Kiesau, U Eikmanns, Z Gutowski-Eckel, S Weber, M Hammelmann, K D Entian, Evidence for a multimeric subtilin synthetase complex. Journal of Bacteriology. ,vol. 179, pp. 1475- 1481 ,(1997) , 10.1128/JB.179.5.1475-1481.1997
Harley H McAdams, Adam Arkin, None, It’s a noisy business! Genetic regulation at the nanomolar scale Trends in Genetics. ,vol. 15, pp. 65- 69 ,(1999) , 10.1016/S0168-9525(98)01659-X
H. H. McAdams, A. Arkin, Stochastic mechanisms in gene expression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 814- 819 ,(1997) , 10.1073/PNAS.94.3.814
Christopher V. Rao, Denise M. Wolf, Adam P. Arkin, Control, exploitation and tolerance of intracellular noise Nature. ,vol. 420, pp. 231- 237 ,(2002) , 10.1038/NATURE01258