18F-FDOPA PET/CT accurately identifies MEN1-associated pheochromocytoma.

摘要: Summary Pheochromocytoma (PHEO) in multiple endocrine neoplasia type 1 (MEN1) is extremely rare. The incidence reported as less than 2%. We report a case of 76-year-old male with familial MEN1 who was found to have unilateral PHEO. Although the patient normotensive and asymptomatic, routine screening imaging CT demonstrated bilateral adrenal masses. left mass grew from 2.5 3.9 cm over 4 years attenuation values 9 Hounsfield units (HU) pre-contrast 15 HU post-contrast washout. Laboratory evaluation an adrenergic biochemical phenotype. Both 18F-fluorodeoxyglucose (18F-FDG) PET/CT 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy uptake. In contrast, 18F-fluorodihydroxyphenylalanine (18F-FDOPA) uptake (28.7 standardized value (SUV)) physiologic right underwent uneventful adrenalectomy pathology consistent for Post-operatively, he had normalization. A review literature suggests that tumors >2 may be at higher risk pheochromocytoma patients MEN1. Despite lack symptoms related catecholamine excess, enlarging nodules should biochemically screened 18F-FDOPA beneficial localization these patients. Learning points modality identifying Adrenal adenomas undergo workup PHEO can serious peri-operative complications if not recognized, given frequent surgical interventions. implicated tumorigenesis this patient.