Glycosylation and liver cancer.

摘要: Liver cancer is the fifth most common cancer, but second leading cause of death, in world, with more than 700,000 fatalities annually. The major etiology liver infection an hepatotropic virus such as hepatitis B or C infection. While chronic viral remains main disease and risk hepatocellular carcinoma (HCC), rates nonviral-associated HCC are occurring at alarmingly increasing rate. Like many cancers, survival closely associated time detection. If caught early, can be high 50%. Regrettably, cases late where low 2-7%. Thus, there has been great interest discovering serum biomarkers that could used to identify those HCC. To this end, groups have examined N-linked glycans changes occur As secretes vast majority proteins into serum, often a starting point for study. In alterations core fucosylation, outer-arm increased sialylation, glycan branching observed patients Similar findings found directly tissue suggesting these may play role tumor formation development.