Mast cells and asthma. The role of mast cell mediators in the pathogenesis of allergic asthma.

摘要: Upon a specific allergic reaction mediators released from mast cells found free in the bronchial lumen or epithelial surface loosen interepithelial cell tight-junctions allowing entrance of more allergen to deeper cells. The primary and secondary thereby generated induce further increased vascular permeability which leads plasma proteins platelets. other immediate responses induced by mediator release are smooth muscle constriction, mucus secretion leukocyte chemoattraction. Vagal afferent reflex efferent stimulation histamine probably might contribute both bronchospasm as well mucous gland secretion. Subacute include cellular infiltrates, mucosal edema, desquamation, basement membrane thickening, goblet hyperplasia These may occur because continued effects caused granule matrix-derived factors. It can thus be seen that many pathologic features asthma attributed degranulation.