MDR1/P-GP expression as a prognostic factor in acute leukemias.
作者： Jean-Pierre Marie , Ollivier Legrand
DOI: 10.1007/978-1-4615-4811-9_1
关键词:
摘要: P-glycoprotein (P-gp) is often expressed (40–50%) on leukemic cells at diagnosis in acute myelogenous leukemia (AML), and even more frequently present after treatment failure. Several large cohorts of newly diagnosed AML patients treated with a classical anthracycline + standard doses cytosine arabinoside were tested for the prognosis value MDR1 phenotype, demonstrated an high correlation between significant increase gene expression failure (or, better, drug resistance).
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