Transcriptional Control of the Cardiac Conduction System

摘要: Abstract Cardiovascular disease, often claiming lives through arrhythmias, is a major cause of mortality in western societies. The cardiac conduction system (CCS) responsible for the initiation, coordination, and synchronization heartbeat. CCS dysfunction, which can result from improper embryonic heart development, directly leads to arrhythmias sudden death. Research past century has culminated our current extensive yet incomplete understanding morphology, function, molecular signature, regulatory cues governing its formation. In combination with growing number markers sensitive functional assays, mouse models continue be instrumental unraveling this dynamic process while highlighting importance transcriptional control.