Muscle histology and creatine kinase levels in the foetus in Duchenne muscular dystrophy

摘要: X-LINKED Duchenne muscular dystrophy is a serious genetic disorder for which at present there no effective treatment. It characterised by progressive muscle wasting and weakness first becomes apparent around the age of 3–5 years, leading to death usually before 20 (ref. 1). A proportion female heterozygous carriers have significantly elevated serum levels creatine kinase woman who found be high risk having an affected son can elect amniocentesis with antenatal foetal sexing selective abortion any male foetus. such aborted foetuses will, however, normal but since cause not known it yet possible diagnose foetus in utero. As step this direction we examined histology serum, amniotic fluid number therapeutically dystrophy. We report that histology, possibly level kinase, may abnormal even second trimester pregnancy.