Novel Mutations in the RAD3 and SSL1 Genes Perturb Genome Stability by Stimulating Recombination Between Short Repeats in Saccharomyces cerevisiae
作者： G. M. Manthey , S. Maines , Xuli Wu , A. M. Bailis , M. C. Negritto
DOI: 10.1093/GENETICS/150.3.963
关键词:
摘要: Maintaining genome stability requires that recombination between repetitive sequences be avoided. Because short, are the most abundant, below a certain length selectively restricted. Novel alleles of RAD3 and SSL1 genes, which code for components basal transcription UV-damage-repair complex in Saccharomyces cerevisiae, have been found to stimulate repeated sequences. In double mutants, these effects suppressed, indicating gene products work together influencing stability. Genetic analysis indicates this function is independent UV-damage repair mutation avoidance, supporting notion play novel role maintenance integrity.
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