Aza-Michael addition of chiral hydrazines to alkylidene malonates
作者： Auxiliadora Prieto , Rosario Fernández , José M. Lassaletta , Juan Vázquez , Eleuterio Alvarez
DOI: 10.1016/J.TET.2005.03.006
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摘要: Abstract The conjugate spontaneous addition of chiral N,N-dialkylhydrazines 1 to dimethyl alkylidene/arylidene malonates 2 , 5–10 affords the corresponding β-hydrazino esters in moderate-to-good yields and selectivities. d -Mannitol-derived hydrazine 1a afforded best results, mainly due higher stability products 3 11–16 .
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