Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity
作者： AndrS. Campos Neves , Maria Luisa Se Melo , Maria JosS.M. Moreno , Elisirio J. Tavares da Silva , Jorge A.R. Salvador
DOI: 10.1016/S0040-4020(98)01138-7
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摘要: … Under these combined conditions,gb, c ie chloroiridie acid with aqueous isopropanol and hypophosphorous acid, we were able to obtain the 3~-axial alcohol 2 in 60 % yield after …
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core.ac.uk 参考文章(48)
K W Gee, N C Lan, L D McCauley, A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. Critical Reviews in Neurobiology. ,vol. 9, pp. 207- 227 ,(1995)
D. F. V. Lewis, Cytochromes P450: structure, function and mechanism. Cytochromes P450: structure, function and mechanism.. ,(1996)
F. J. Zeelen, Medicinal chemistry of steroids ,(1990)
Rudi van Eldik, Colin D. Hubbard, Chemistry under extreme or non-classical conditions John Wiley , Spektrum. ,(1996)
Bernard Testa, Urs A Meyer, Bernard, Meyer Testa, Advances in Drug Research Published in <b>1997</b> by Academic Press. ,(1964)
Derek Barton, W.David Ollis, Comprehensive organic chemistry : the synthesis and reactions of organic compounds Tetrahedron Letters. ,vol. 19, ,(1978) , 10.1016/S0040-4039(01)85753-1
An Improved Preparation of Aromatase Inhibitor 4-Hydroxyandrost-4-ene-3,17-dione Synthetic Communications. ,vol. 22, pp. 1949- 1952 ,(2006) , 10.1080/00397919208021325
K Höffken, W Jonat, K Possinger, M Kölbel, T Kunz, H Wagner, R Becher, R Callies, P Friederich, W Willmanns, Aromatase inhibition with 4-hydroxyandrostenedione in the treatment of postmenopausal patients with advanced breast cancer: a phase II study. Journal of Clinical Oncology. ,vol. 8, pp. 875- 880 ,(1990) , 10.1200/JCO.1990.8.5.875
Mori Makoto, Ikegami Shiro, Tamaoki Bun-ichi, Novel epimerizatton of steroidal allylic alcohols Steroids. ,vol. 33, pp. 467- 476 ,(1979) , 10.1016/0039-128X(79)90019-9
M. Harnik, Studies in syntheses of steroid metabolites. Part IV Steroids. ,vol. 3, pp. 359- 379 ,(1963) , 10.1016/0039-128X(64)90001-7