Different brain networks underlying intelligence in Autism Spectrum Disorders and Typically Developing Children

摘要: There has been sustained clinical and cognitive neuroscience research interest in the neural basis of intelligence. The characterisation brain structure function underlying performance is necessary to understand neurodevelopment intelligence across lifespan, how associated correlates could be perturbed atypical populations. As most work this area focused on neurotypical adults, nature functional connectivity paediatric cohorts with or without abnormal requires further investigation. We use network-based statistics (NBS) examine association between resting-state Magnetic Resonance Imaging (fMRI) fluid ability male children Autism Spectrum Disorders (ASD; M=10.45, SD=1.58 years, n=26) matched controls (M=10.38, SD=0.96 years). Compared typically developing strictly age, sex scores, boys ASD displayed a subnetwork (network size=24, p=.0373, FWE-corrected) significantly increased associations performance. Between-group differences remained significant at higher edge threshold t=4 (size=6, p=.0425, FWE-corrected). Results were validated independent-site replication analyses representing similar cohort size=14, p=.0396, Regions implicated angular gyrus, posterior middle temporal occipital temporo-occipital regions. Across all sites, within-group failed identify subnetworks general males. Findings suggest prematurely accelerated but aberrant development young males, possibly as compensation mechanism that supports equivalent task controls. absence whole-brain network males may represent shift from local global integration ability.