In-situ radioactive medical device

摘要: Devices and methods for rendering an intravascular stent radioactive in-situ, after placement. A is provided having a tubular body first substance immobilized on body. The preferably has high selective affinity second which can be radioactive, cytotoxic or thrombolytic. also have growth factors thrombolytic, chemolytic agents. placed across stenosed blood vessel region, dilation by angioplasty atherectomy. After placement within the vessel, injected into stream of patient. With each pass through stent, increasingly bound to stent. Suitable complementary pairs include avidin radio-labeled biotin, protamine heparin, protein anti-protein antibody.