Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis

摘要: Abstract Although numerous studies have suggested that pharmacological alteration of the dopamine (DA) system modulates reward discounting, these produced inconsistent findings. Here, we conducted a systematic review and pre-registered meta-analysis to evaluate DA drug-mediated effects on discounting time, probability, effort costs in healthy rats. This total 1,343 articles screen for inclusion/exclusion. From literature, identified 117 from approximately 1,549 individual Using random-effects with maximum-likelihood estimation, meta-analyzed placebo-controlled drug (1) D1-like receptor agonists (2) antagonists, (3) D2-like (4) (5) transporter-modulating drugs. Meta-analytic showed DAT-modulating drugs decreased discounting. While antagonists both increased agonist those receptors had no significant effect behavior. A number appear contingent study design features like cost type, rat strain, microinfusion location. These findings suggest nuanced relationship between behavior urge caution when drawing generalizations about pharmacologically manipulating reward-based decision making.