Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet.

摘要: Elevated homocysteine has been identified as an independent risk factor for cardiovascular and cerebrovascular disease. Although multivitamin use associated with low plasma concentrations in several observational studies, no clinical trials have conducted using multivitamin/mineral supplements to lower homocysteine. We determined whether a supplement formulated at about 100% Daily Value will further concentration improve B-vitamin status healthy older adults already consuming diet fortified folic acid. In this randomized, double-blind, placebo-controlled trial, 80 free-living men women aged 50-87 y total of > or =8 micromol/L received either placebo 56 d while their usual diet. After the 8-wk treatment, subjects taking had significantly higher than controls (P: < 0.01). Plasma folate, pyridoxal phosphate (PLP) vitamin B-12 were increased 41.6, 36.5 13.8%, respectively, supplemented group, whereas changes observed group. The mean decreased 9.6% group 0.001) was unaffected There significant dietary intake during intervention. Multivitamin/mineral supplementation can reduce folate-fortified