Studies of Nucleosides and Nucleotides. XXXVIII. Synthesis of 8-Bromoadenosine Nucleotides

作者: MORIO IKEHARA , SEIICHI UESUGI

DOI: 10.1248/CPB.17.348

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摘要: Direct bromination of adenine nucleotides was achieved by the use bromine-water as brominating agent in alkaline or buffer solution. By this method 8-bromoadenosine 2-', 3'-and 5'-monophosphate, 5'-di- and tri-phosphate, 3', 5'-cyclic phosphate were synthesized satisfactory yield. Mechanism discussed.

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