Serological evidence of Mycoplasma pneumoniae infection in acute exacerbation of COPD

摘要: Abstract A prospective study was conducted to identify and characterize hospitalizations for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with serologic evidence infection Mycoplasma pneumoniae (Mp). Two hundred forty AECOPD were included in a 17-month study. Paired sera obtained each the tested serologically Mp using commercial enzyme immunoassay (EIA) kit. Only significant changes, according formula manufacturer’s instructions, antibody titers IgM and/or IgG IgA considered diagnostic infection. In 34 (14.2%) tests positive (MpH). 29 these (85%) change found. 11 (32%) only identified IgA. 24 MpH (71%) there at least one other respiratory pathogen. comparison 206 without Mp, had higher rates inhaled steroid therapy (41% vs. 24%, p = 0.033) longer time interval between appearance dyspnea hospitalization (6.6 ± 3.8 days 5.0 3.5 days, 0.012). There no differences two groups broad spectrum patient- exacerbation-related clinical variables. Specific antibiotic group did not shorten hospital stay. Serologic is common patients hospitalized AECOPD, usually based on changes specific titers. most another pathogen can be identified. The vast majority characteristics are same Mp. practical implications findings should clarified further studies.