Tumor Necrosis Factor-α and the Myocardial Stress Response

摘要: The ability of the myocardium to successfully compensate for and adapt stress, such as a superimposed hemodynamic overload and/or myocardial ischemia/infarction, ultimately determines whether heart will decompensate fail, or instead it maintain preserved function. As shown in Figure 1, adult adapts environmental stress by at least three interrelated integrated mechanisms: cardiac hypertrophy, remodeling repair. However, while is becoming increasingly clear that cell types residing within mammalian both produce respond synthesizing variety soluble protein factors are capable interacting an autocrine paracrine fashion, molecules mediate integrate response level intact myocyte ventricle whole, remain poorly understood.