Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics

摘要: Vesicles formed by self-assembly of lipids and surfactants are increasingly recognised as carriers for drug delivery applications in disease targeting many other biomedical-related areas, demonstrable the growing number significant publications. This manuscript reviews important facets lipid-based vesicles their surface modifications to achieve controlled release selective cell targeting. We cover both more commonly used ionic phospholipid vesicle rapidly field non-ionic vesicles/niosomes using uncharged amphiphilic molecules, which could be sugar or glycolipids, sorbitan esters, polyoxyethylene alkyl ethers. Due lower cost, biodegradability, low-toxicity, low-immunogenicity specific sugar-cell recognition, much attention would devoted glycolipid bio-surfactants potential targeted delivery. Specifically, our review points design consideration lipid surfactant nano-carriers based on critical packing parameter, membrane curvature, effects hydrophobic chain structures. have also dedicated a section this summarise some novel various liquid crystal phases delivery, how turn these related chemical structures entities. The final outlines application agents diagnostic imaging.