Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System.
作者： Aravind S. Kshatri , Alberto Gonzalez-Hernandez , Teresa Giraldez
关键词:
摘要: Within the potassium ion channel family, calcium activated (KCa) channels are unique in their ability to couple intracellular Ca2+ signals membrane potential variations. KCa diversely distributed throughout central nervous system and play fundamental roles ranging from regulating neuronal excitability controlling neurotransmitter release. The physiological versatility of is enhanced by alternative splicing co-assembly with auxiliary subunits, leading differences distribution, subunit composition pharmacological profiles. Thus, understanding specific channels’ mechanisms function challenging. Based on single conductance, divided into three subtypes: small (SK, 4-14 pS), intermediate (IK, 32-39 pS) big (BK, 200-300 channels. This review describes biophysical characteristics these channels, as well pathological implications. In addition, we also discuss current strategies challenges target for treatment various neurological psychiatric disorders.
frontiersin.org
sci-hub.se 参考文章(251)
Susanne Jϕrgensen, Tina H. Johansen, Tino Dyhring, Fluorescence-Based Tl + −Influx Assays as a Novel Approach for Characterization of Small-Conductance Ca 2+ −Activated K + Channel Modulators Methods of Molecular Biology. ,vol. 491, pp. 257- 266 ,(2008) , 10.1007/978-1-59745-526-8_20
Furong Wang, Yu Zhang, Li Wang, Peng Sun, Xianwen Luo, Yasuhito Ishigaki, Tokio Sugai, Ryo Yamamoto, Nobuo Kato, Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice. Neuropharmacology. ,vol. 97, pp. 210- 219 ,(2015) , 10.1016/J.NEUROPHARM.2015.05.027
D. James Surmeier, Jaime N. Guzman, Javier Sanchez-Padilla, Joshua A. Goldberg, What causes the death of dopaminergic neurons in Parkinson's disease? Progress in Brain Research. ,vol. 183, pp. 59- 77 ,(2010) , 10.1016/S0079-6123(10)83004-3
TA Longden, KM Dunn, HJ Draheim, MT Nelson, AH Weston, G Edwards, Intermediate‐conductance calcium‐activated potassium channels participate in neurovascular coupling British Journal of Pharmacology. ,vol. 164, pp. 922- 933 ,(2011) , 10.1111/J.1476-5381.2011.01447.X
R J Large, A Kshatri, T I Webb, S Roy, A Akande, E Bradley, G P Sergeant, K D Thornbury, N G McHale, M A Hollywood, Effects of the novel BK (KCa1.1) channel opener GoSlo‐SR‐5‐130 are dependent on the presence of BKβ subunits British Journal of Pharmacology. ,vol. 172, pp. 2544- 2556 ,(2015) , 10.1111/BPH.13085
C H Feetham, N Nunn, R Lewis, C Dart, R Barrett-Jolley, TRPV4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus British Journal of Pharmacology. ,vol. 172, pp. 1753- 1768 ,(2015) , 10.1111/BPH.13023
John P Adelman, SK channels and calmodulin. Channels. ,vol. 10, pp. 1- 6 ,(2016) , 10.1080/19336950.2015.1029688
Matthew Schreiber, Alex Yuan, Lawrence Salkoff, Transplantable sites confer calcium sensitivity to BK channels Nature Neuroscience. ,vol. 2, pp. 416- 421 ,(1999) , 10.1038/8077
Anis Contractor, Vitaly A. Klyachko, Carlos Portera-Cailliau, Altered neuronal and circuit excitability in Fragile X Syndrome Neuron. ,vol. 87, pp. 699- 715 ,(2015) , 10.1016/J.NEURON.2015.06.017
HG Knaus, C Schwarzer, RO Koch, A Eberhart, GJ Kaczorowski, H Glossmann, F Wunder, O Pongs, ML Garcia, G Sperk, Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals The Journal of Neuroscience. ,vol. 16, pp. 955- 963 ,(1996) , 10.1523/JNEUROSCI.16-03-00955.1996