Biodegradable PEG Hydrogels Cross-linked Using Biotin-Avidin Interactions
作者： Yingkai Liu , Jingquan Liu , Jiangtao Xu , Shengyu Feng , Thomas P. Davis
DOI: 10.1071/CH10168
关键词:
摘要: Poly(ethylene glycol) (PEG) hydrogels are water-swellable, non-toxic, non-immunogenic, and biocompatible. In this paper, we describe the generation of biodegradable PEG by cross-linking biotinylated oligomers containing intrinsic disulfide bonds via biotin-avidin interactions. The were synthesized condensation reaction between 3,3'-dithiodipropionic acid, followed with biotin. This methodology obviates need for potentially toxic chemical agents that usually used in common preparation hydrogels. Therefore it may be particularly useful biomedical or pharmaceutical applications.
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