Mechanistic Insights for Block Copolymer Morphologies: How Do Worms Form Vesicles?

摘要: Amphiphilic diblock copolymers composed of two covalently linked, chemically distinct chains can be considered to biological mimics cell membrane-forming lipid molecules, but with typically more than an order magnitude increase in molecular weight. These macromolecular amphiphiles are known form a wide range nanostructures (spheres, worms, vesicles, etc.) solvents that selective for one the blocks. However, such self-assembly is usually limited dilute copolymer solutions (<1%), which significant disadvantage potential commercial applications as drug delivery and coatings. In principle, this problem circumvented by polymerization-induced block self-assembly. Here we detail synthesis subsequent situ amphiphilic AB pot concentrated aqueous dispersion polymerization formulation. We show spherical micelles, wormlike vesicles predictably efficiently obtained (within 2 ...