Postsynaptic Determinants of Inhibitory Transmission at Mixed GABAergic/Glycinergic Synapses

摘要: In the vertebrate central nervous system, ionotropic inhibition is mediated by two neurotransmitters: GABA and glycine. While inhibitory neurons of forebrain release mainly GABA, both neurotransmitters coexist in most structures hindbrain. More specifically, a majority hindbrain contain glycine that accumulate same vesicle are co-released. On postsynaptic side, activate separate chloride-permeant receptors display similar biophysical properties. We review here distribution organization co-transmission, with an emphasis on side synapse. show very different types functional have been adopted mixed circuits. However one rule always preserved: GABAergic glycinergic components synapses decay kinetics. GABAA receptor kinetics determined combination rich variety subunits. contrast assembled from small number subunits adult may express type. Accumulating evidence suggests synaptic currents could be modulated activity dependant manner, through various mechanisms. conclusion we propose tunable timecourse optimize rate-coding circuits whereas coding oscillations synchrony benefit rigid yet diverse subunit receptors.