Mechanisms of topoisomerase I inhibition by anticancer drugs
作者： Yves Pommier , Akihiko Tanizawa , Kurt W. Kohn
DOI: 10.1016/S1054-3589(08)61132-1
关键词:
摘要: Topoisomerase I (top1) is a validated target for cancer chemotherapy (1-3) since its identification as the sole of camptothecin (4). The sodium salt was found to be clinically active but use discontinued in 70’s because severe side effects and lack understanding drug’s mechanism action (5). finding 1985 that specifically poisons top1 has generated great interest find water-soluble, more efficacious less toxic analogues camptothecin.
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