Neuropathy Is Not Associated With Clinical Outcomes in Patients Receiving Adjuvant Taxane-Containing Therapy for Operable Breast Cancer
作者： Bryan P. Schneider , Fengmin Zhao , Molin Wang , Vered Stearns , Silvana Martino
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摘要: Purpose Neuropathy is a common and potentially disabling complication of adjuvant taxane therapy. Recent studies have identified candidate single nucleotide polymorphisms associated with taxane-induced neuropathy. Therefore, we sought to determine whether neuropathy was breast cancer recurrence in clinical trial population who received Patients Methods Trial E1199 included 4,554 eligible women operable up four cycles doxorubicin cyclophosphamide every 3 weeks followed by paclitaxel 175 mg/m2 for (P3), 80 weekly 12 (P1), docetaxel 100 (D3), or 35 (D1). A Cox proportional hazards model used the relationship between disease-free survival (DFS), overall (OS), recurrence-free (RFS) treating status as time dependent covariate ...
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