The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.

摘要: Background: The current paper includes a systematic search of the literature, detailed presentation results, and grading treatment options in terms efficacy tolerability/ safety. Material Methods: PRISMA method was used literature with combination words 'bipolar,' 'manic,' 'mania,' 'manic depression,' depressive' 'randomized,' 'algorithms' 'manic- depressive,' or depression.' Relevant web pages review articles were also reviewed. Results: report is based on analysis 57 guideline papers 531 published related to RCTs, reviews, posthoc, meta- March 25, 2016. specific for acute mania, mixed episodes, bipolar depression, maintenance phase, psychotic features, anxiety, rapid cycling evaluated regards efficacy. Existing guidelines Finally, Tables reflecting recommendation levels created that led development precise algorithm still has prove its feasibility everyday clinical practice. Conclusions: A conducted pharmacological disorder identify all relevant random controlled trials pertaining aspects graded data according predetermined develop management various phases disorder. It important note some recommendations secondary outcome from posthoc analyses.