(18)F-FDG-PET/CT predicts early tumor recurrence in living donor liver transplantation for hepatocellular carcinoma.
作者： Seung Duk Lee , Seong Hoon Kim , Young-Kyu Kim , Chulhan Kim , Seok-Ki Kim
DOI: 10.1111/J.1432-2277.2012.01572.X
关键词:
摘要: Abstract The prognosis including (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for the early recurrence hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT) was not well established. Consecutive patients who underwent (18)F-FDG-PET/CT and subsequent LDLT HCC from March 2005 to June 2011 were enrolled. 191 with a median follow-up of 26.1 months evaluated. There 20 (10.5%) (≤6 months), 18 (9.4%) late (>6 153 (80.1%) no recurrence. Fifty-five (28.8%) displayed increased PET/CT tumor uptake. Three-year overall disease-free survival PET/CT-positive 65.5% 57.1%, respectively, while PET/CT-negative showed respective values 89.8% 86.8% (P = 0.001 vs. P < 0.001). Tumor variables associated finding preoperative AFP level, Milan, UCSF criteria, maximum size, total differentiation, vascular invasion, serosal invasion. status identified as an independent prognostic factor influencing in multivariable analysis (HR 3.945, 95% CI 1.196-13.016, 0.024). is significant predictor HCC.
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