Novel Mitotic Targets and Their Small-Molecule Inhibitors

摘要: With several successful anticancer drugs on the market and numerous compounds in clinical developments, antimitotic agents represent an important category of agents. However, utility tubulin-binding is somewhat limited due to multiple drug resistance (MDR), poor pharmacokinetics therapeutic index. There ongoing need for modulators other intracellular targets that result same anti-mitotic effect without adverse effects "traditional" tubulin binders. This review describes progress made to-date development novel emerging biotargets affecting mitotic events, their small-molecule modulators.