Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target.
作者： Edward P. Retzbach , Stephanie A. Sheehan , Evan M. Nevel , Amber Batra , Tran Phi
DOI: 10.1016/J.ORALONCOLOGY.2018.01.011
关键词:
摘要: Oral cancer has become one of the most aggressive types cancer, killing 140,000 people worldwide every year. Current treatments for oral include surgery and radiation therapies. These procedures can be very effective; however, they also drastically decrease quality life survivors. New chemotherapeutic are needed to more effectively combat cancer. The transmembrane receptor podoplanin (PDPN) emerged as a functionally relevant biomarker target. PDPN expression promotes tumor cell migration leading invasion metastasis. Here, we describe role in squamous carcinoma progression, how it may exploited prevent treat
elsevier.com
sci-hub.se 参考文章(183)
Mika Kato Kaneko, Yukinari Kato, Akihiko Kameyama, Hiromi Ito, Atsushi Kuno, Jun Hirabayashi, Tomomi Kubota, Koh Amano, Yasunori Chiba, Yasushi Hasegawa, Isoji Sasagawa, Kazuhiko Mishima, Hisashi Narimatsu, Functional glycosylation of human podoplanin: Glycan structure of platelet aggregation-inducing factor FEBS Letters. ,vol. 581, pp. 331- 336 ,(2007) , 10.1016/J.FEBSLET.2006.12.044
A. Wetterwald, W. Hofstetter, M.G. Cecchini, B. Lanske, C. Wagner, H. Fleisch, M. Atkinson, Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone. ,vol. 18, pp. 125- 132 ,(1996) , 10.1016/8756-3282(95)00457-2
Claudiu Mărgăritescu, Daniel Pirici, Alin Stîngă, Cristiana Simionescu, Marius Raica, Laurentiu Mogoantă, Alex Stepan, Domenico Ribatti, None, VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study Clinical and Experimental Medicine. ,vol. 10, pp. 209- 214 ,(2010) , 10.1007/S10238-010-0095-4
Harini Krishnan, Jhon A. Ochoa-Alvarez, Yongquan Shen, Evan Nevel, Meenakshi Lakshminarayanan, Mary C. Williams, Maria I. Ramirez, W. Todd Miller, Gary S. Goldberg, Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility Journal of Biological Chemistry. ,vol. 288, pp. 12215- 12221 ,(2013) , 10.1074/JBC.C112.446823
D R Sutherland, D Bailey, J Iglesias, J Law, M Lei, H Yeger, D Banerjee, R Baumal, A Marks, Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. British Journal of Cancer. ,vol. 80, pp. 569- 578 ,(1999) , 10.1038/SJ.BJC.6690393
Z.P. Pavelic, M. Lasmar, LJ Pavelic, C. Sorensen, PJ Stambrook, N. Zimmermann, J.J Gluckman, Absence of Retinoblastoma gene product in human primary oral cavity carcinoma European Journal of Cancer Part B: Oral Oncology. ,vol. 32, pp. 347- 351 ,(1996) , 10.1016/0964-1955(96)00025-5
Suguru Ito, Genichiro Ishii, Ayuko Hoshino, Hiroko Hashimoto, Shinya Neri, Takeshi Kuwata, Morihiro Higashi, Kanji Nagai, Atsushi Ochiai, Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity Biochemical and Biophysical Research Communications. ,vol. 422, pp. 194- 199 ,(2012) , 10.1016/J.BBRC.2012.04.158
Yongquan Shen, Zhenyu Jia, Robert G. Nagele, Hitoshi Ichikawa, Gary S. Goldberg, Src Uses Cas to Suppress Fhl1 in Order to Promote Nonanchored Growth and Migration of Tumor Cells Cancer Research. ,vol. 66, pp. 1543- 1552 ,(2006) , 10.1158/0008-5472.CAN-05-3152
Leah N. Cueni, Michael Detmar, Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Experimental Cell Research. ,vol. 315, pp. 1715- 1723 ,(2009) , 10.1016/J.YEXCR.2009.02.021
Hong Qin, Qing Shao, Heather Curtis, Jacques Galipeau, Daniel J. Belliveau, Taiqi Wang, Moulay A. Alaoui-Jamali, Dale W. Laird, Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. Journal of Biological Chemistry. ,vol. 277, pp. 29132- 29138 ,(2002) , 10.1074/JBC.M200797200