Search for Intrafamilial Transmission of Hepatitis C Virus in Hemophilia Patients

摘要: This study was performed to determine the risk of family members anti-hepatitis C virus (HCV)-positive hemophilia patients (index patients) for infection with HCV compared acquiring hepatitis B (HBV), human immunodeficiency (HIV), and A (HAV) infection. All index (n = 141) were found be positive by first second generation anti-HCV enzyme immunoassays (EIAs). Among their household contacts 228), 224 negative 1 both assays. Three gave results in EIA assay. latter result confirmed further tests (neutralization test, synthetic peptides, supplemental assay). Percent positivity anti-HBc about same non-sexual sexual partners (13 109 [12%] 7 54 [13%], respectively). prevalence higher chronic than those who had recovered from that disease (6 20 [30%] 14 133 [10%], respectively; P < .05). The HBV rate participating controlled self-treatment not controls (3 57 [5%] 10 98 Of 44 partners, 5 (11%) anti-HIV. Prevalence anti-HAV matched age-related distribution German population. These findings suggest intrafamilial transmission is uncommon. In patients, seems as high contacts. Participation does appear an additional There no doubt less common HIV.