Prolonged cardiac arrest and resuscitation by extracorporeal life support: favourable outcome without preceding anticoagulation in an experimental setting:

摘要: State-of-the-art cardiopulmonary resuscitation (CPR) restores circulation with inconsistent blood-flow and pressure. Extracorporeal life support (ECLS) following CPR opens the opportunity for “controlled reperfusion”. In animal experiments investigating ECLS, systemic anticoagulation before induced cardiac arrest is normal, but a major point of dispute, since preliminary heparinization in patients undergoing unwitnessed impossible. this study, we investigated options ECLS after an experimental 15 minutes normothermic arrest, without preceding anticoagulation, pigs. Neurological recovery was assessed by scoring system, electroencephalography brain magnetic resonance imaging. Additionally, histology performed on day seven arrest. We demonstrated that heparin administration not necessary survival or neurological setting. Heparin flushing cannulae seemed sufficient to avoid thrombus formation...