Regulation of Brain Volume Under Isosmotic and Anisosmotic Conditions

摘要: The incompressibility of the contents skull — brain, blood, and cerebrospinal fluid (CSF) implies that their total volume must remain constant; changes in one compartment be accompanied by reciprocal others. This relationship, known as Monro-Kellie doctrine, makes central nervous system especially vulnerable to increases tissue volume. Small brain bulk may “buffered” decreases CSF volume; however, larger will progressively reduce cerebral blood flow, cause mechanical damage, lead herniation through foramen magnum death. importance regulation at cellular level, apart from its contribution bulk, has not been studied extensively. However, analyses neuronal activity invertebrate systems provide indirect evidence maintenance normal cell is essential for a variety functions, including generation axonal action potentials (Pichon Treherne 1976) synaptic (Prior Pierce 1981).