The dynamics of HMG protein–chromatin interactions in living cellsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

摘要: The dynamic interaction between nuclear proteins and chromatin leads to the functional plasticity necessary mount adequate responses regulatory signals. Here, we review factors regulating interactions of high mobility group (HMGs), an abundant ubiquitous superfamily chromatin-binding in living cells. HMGs are highly mobile interact with fiber a fashion, as part protein network. major that affect binding operative at level single nucleosome. These include structural features HMGs, competition other for nucleosome sites, complex formation partners, post-translational modifications or sites. versatile modulation HMG plays role processes establish cellular phenotype.